So, we're back to using memes to draft. This time about Lasix, aka Furosemide.
THE LOOP DIURETICS (eg. furosemide) act at the thick, ascending limb of the loop of Henle, which is impermeable to water.
1. Sodium and chloride cotransport is blocked due to inhibition of the Na+/K+/2Cl- transporter.
2. A marked diuresis is produced because large amounts of sodium are normally reabsorbed at this site.
3. Loop diuretics are effective when taken orally and are eliminated by active proximal tubular secretion.
Side effects are more common than with thiazides and include:
a. Hypovolemia, due to rapid, large decrease in blood volume.
b. Hyponatremia.
c. Hypokalemia, which increases the risk of atrial and ventricular arrhythmias.
d. Hyperuricemia, which can cause or exacerbate attacks of gout.
