Pathophysiology HHS has similar pathophysiology to DKA but with some mild dissimilarities. The hallmark of both conditions is the deficiency of insulin. As a consequence of deficiency of this key hormone, there is decrease glucose utilization by the peripheral tissue causing hyperglycemia. The peripheral tissues enter a state of “starvation” The release of counterregulatory hormones glucagon, growth hormone, cortisol, and catecholamines stimulates gluconeogenesis and glycogenolysis. This creates a system of vicious cycle where there is increase level of glucose in the serum but decreases uptake by the peripheral tissues for tissue metabolism. (A follow up to the one on Autism done in the group!) #Simplified #Meme
